Sumo tablet : composition, uses, side effects and benefits

Are you tired of living with chronic pain and inflammation? Do you struggle to find relief from debilitating conditions like arthritis, menstrual cramps, or muscle strain? Look no further than Sumo Tablets, the powerful and effective solution to your pain management needs!

Pain and inflammation are debilitating conditions that affect millions of people worldwide.

Whether it's arthritis, menstrual cramps, muscle strain, or post-operative pain, finding effective relief can be a challenge. In recent years, combination therapies have gained popularity for their ability to provide rapid and sustained relief from pain and inflammation.

One such medication is Sumo Tablets, a dual-action formula that combines the anti-inflammatory properties of Nimesulide with the pain-relieving effects of Paracetamol.

In this article, we will delve into the composition, mechanism of action, and benefits of Sumo Tablets, exploring their potential as a valuable addition to pain management regimens.

Composition of Sumo tablet

The composition of Sumo Tablet typically includes:

Nimesulide (100mg): A nonsteroidal anti-inflammatory drug (NSAID) that helps to relieve pain, reduce inflammation, and lower fever.

Paracetamol (325mg): A pain reliever and antipyretic that helps to relieve headaches, fever, and minor aches and pains.

Inactive Ingredients:

Microcrystalline Cellulose: A filler that helps to bind the ingredients together.

Croscarmellose Sodium: A disintegrant that helps the tablet to dissolve in the body.

Magnesium Stearate: A lubricant that helps the tablet to be compressed and released smoothly.

Colloidal Silicon Dioxide: An anti-caking agent that helps to prevent the ingredients from sticking together.

Talc: An anti-caking agent that helps to prevent the ingredients from sticking together.

Colorants:

Titanium Dioxide: A colorant that gives the tablet its white color.

Note: The exact composition of Sumo Tablet may vary depending on the manufacturer and country of origin. Always check the packaging or consult with a healthcare professional for the most up-to-date and accurate information.

Mode of Action of Sumo Tablets: A Dual-Action Approach to Pain Relief

Sumo Tablets are a combination medication that contains Nimesulide (100mg) and Paracetamol (325mg). This dual-action formula works synergistically to provide rapid and sustained relief from pain and inflammation.

Nimesulide: Anti-Inflammatory Action

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. Nimesulide selectively inhibits the enzyme cyclooxygenase-2 (COX-2), which is responsible for the production of prostaglandins in inflammatory tissues.

The anti-inflammatory action of Nimesulide can be attributed to:

Inhibition of COX-2: Nimesulide blocks the production of prostaglandins, thereby reducing inflammation and pain.

Inhibition of neutrophil activation: Nimesulide reduces the activation of neutrophils, which are white blood cells that contribute to inflammation.

Antioxidant activity: Nimesulide has antioxidant properties, which help to reduce oxidative stress and inflammation.

Paracetamol: Analgesic and Antipyretic Action

Paracetamol is a well-established analgesic and antipyretic medication that works by:

Inhibiting the production of prostaglandins in the brain: Paracetamol blocks the production of prostaglandins in the brain, thereby reducing pain and fever.

Activating descending pain inhibitory pathways: Paracetamol activates the descending pain inhibitory pathways, which help to reduce pain perception.

The combination of Nimesulide and Paracetamol in Sumo Tablets provides a dual-action approach to pain relief:

Rapid relief from pain: Paracetamol provides rapid relief from pain and fever.

Sustained anti-inflammatory action: Nimesulide provides sustained anti-inflammatory action, reducing inflammation and pain.

Mechanism of Action of Sumo Tablets

The mechanism of action of Sumo Tablets can be summarized as follows:

Nimesulide inhibits the production of prostaglandins in inflammatory tissues, reducing inflammation and pain.

Paracetamol inhibits the production of prostaglandins in the brain, reducing pain and fever.

The combination of Nimesulide and Paracetamol provides rapid and sustained relief from pain and inflammation.

By understanding the mode of action of Sumo Tablets, healthcare professionals can better appreciate the therapeutic benefits of this combination medication and provide effective pain management solutions for their patients.

Indications of Sumo Tablets

Sumo Tablets are a combination medication containing Nimesulide (100mg) and Paracetamol (325mg), indicated for the management of various painful and inflammatory conditions. The indications of Sumo Tablets include:

Musculoskeletal Disorders

Osteoarthritis: Sumo Tablets are indicated for the relief of pain and inflammation associated with osteoarthritis.

Rheumatoid arthritis: Sumo Tablets are indicated for the relief of pain and inflammation associated with rheumatoid arthritis.

Muscle strain and sprains: Sumo Tablets are indicated for the relief of pain and inflammation associated with muscle strain and sprains.

Tendinitis and bursitis: Sumo Tablets are indicated for the relief of pain and inflammation associated with tendinitis and bursitis.

Painful Conditions

Headaches: Sumo Tablets are indicated for the relief of tension headaches and migraines.

Menstrual cramps: Sumo Tablets are indicated for the relief of pain and inflammation associated with menstrual cramps.

Toothaches: Sumo Tablets are indicated for the relief of toothache pain.

Post-operative pain: Sumo Tablets are indicated for the relief of pain and inflammation associated with post-operative pain.

Inflammatory Conditions

Inflammatory arthritis: Sumo Tablets are indicated for the relief of pain and inflammation associated with inflammatory arthritis.

Gout: Sumo Tablets are indicated for the relief of pain and inflammation associated with gout.

Soft tissue injuries: Sumo Tablets are indicated for the relief of pain and inflammation associated with soft tissue injuries.

Other Conditions

Fever: Sumo Tablets are indicated for the reduction of fever.

Post-traumatic pain: Sumo Tablets are indicated for the relief of pain and inflammation associated with post-traumatic pain.

It is essential to note that Sumo Tablets should only be used under the guidance of a healthcare professional and for the indications specified above.

Off-Label Indications of Sumo Tablets

While Sumo Tablets are approved for various indications, some healthcare professionals may prescribe them off-label for other conditions. Keep in mind that off-label use should only be done under the guidance of a qualified healthcare professional.

Some potential off-label indications of Sumo Tablets include:

Fibromyalgia: Sumo Tablets may be used off-label to manage pain and inflammation associated with fibromyalgia.

Neuropathic pain: Sumo Tablets may be used off-label to manage neuropathic pain conditions such as diabetic neuropathy, postherpetic neuralgia, or trigeminal neuralgia.

Migraine prophylaxis: Sumo Tablets may be used off-label to prevent migraines in some patients.

Temporomandibular joint (TMJ) disorders: Sumo Tablets may be used off-label to manage pain and inflammation associated with TMJ disorders.

Surgical pain management: Sumo Tablets may be used off-label to manage pain and inflammation after surgery.

Cancer pain management: Sumo Tablets may be used off-label to manage cancer-related pain.

Rheumatoid arthritis-associated conditions: Sumo Tablets may be used off-label to manage conditions associated with rheumatoid arthritis, such as rheumatoid nodules or vasculitis.

Again, it's essential to emphasize that off-label use of Sumo Tablets should only be done under the guidance of a qualified healthcare professional, and patients should be closely monitored for potential side effects.

Dosage of Sumo Tablets

The dosage of Sumo Tablets varies depending on the condition being treated, the severity of symptoms, and the individual patient's response. Here is a detailed overview of the recommended dosage:

Adult Dosage

Osteoarthritis: 1 tablet (Nimesulide 100mg + Paracetamol 325mg) twice daily, morning and evening.

Rheumatoid arthritis: 1 tablet twice daily, morning and evening.

Muscle strain and sprains: 1 tablet three times daily, morning, afternoon, and evening.

Menstrual cramps: 1 tablet three times daily, morning, afternoon, and evening.

Headaches: 1 tablet as needed, not to exceed 3 tablets in 24 hours.

Pediatric Dosage

Children 12-18 years: 1 tablet (Nimesulide 100mg + Paracetamol 325mg) twice daily, morning and evening, under adult supervision.

Children under 12 years: Not recommended due to lack of safety and efficacy data.

Geriatric Dosage

Elderly patients: 1 tablet (Nimesulide 100mg + Paracetamol 325mg) twice daily, morning and evening, under close medical supervision.

Duration of Treatment

Acute conditions: Treatment should not exceed 3-5 days.

Chronic conditions: Treatment can be continued for a longer duration, but regular monitoring is recommended.

Important Dosage Considerations

Do not exceed the recommended dose: Taking more than the recommended dose can increase the risk of adverse effects.

Do not use for extended periods: Prolonged use can lead to gastrointestinal toxicity, renal impairment, and other adverse effects.

Monitor liver and kidney function: Regular monitoring of liver and kidney function is recommended, especially in patients with pre-existing liver or kidney disease.

It's essential to consult with a healthcare professional before taking Sumo Tablets, especially if you have any underlying medical conditions or are taking other medications.

Side Effects of Sumo Tablets

Sumo Tablets, like all medications, can cause side effects in some individuals. While not everyone will experience side effects, it's essential to be aware of the potential risks. Here's a detailed overview of the possible side effects of Sumo Tablets:

Common Side Effects (≥1% to <10%)

Gastrointestinal disturbances: Nausea, vomiting, diarrhea, abdominal pain, and dyspepsia.

Headache: Mild to moderate headache.

Dizziness: Lightheadedness or dizziness.

Fatigue: Feeling tired or weak.

Rash: Mild skin rash or itching.

Uncommon Side Effects (≥0.1% to <1%)

Gastrointestinal ulcers: Ulcers in the stomach or intestines.

Gastrointestinal bleeding: Bleeding in the stomach or intestines.

Renal impairment: Decreased kidney function.

Elevated liver enzymes: Increased levels of liver enzymes.

Allergic reactions: Severe allergic reactions, including anaphylaxis.

Rare Side Effects (<0.1%)

Severe gastrointestinal reactions: Severe ulcers, bleeding, or perforation.

Stevens-Johnson syndrome: A rare skin and mucous membrane disorder.

Toxic epidermal necrolysis: A rare skin condition.

Aplastic anemia: A rare blood disorder.

Agranulocytosis: A rare blood disorder.

Post-Marketing Surveillance

Cardiovascular events: Rare reports of heart attack, stroke, and cardiac arrhythmias.

Hypersensitivity reactions: Rare reports of severe allergic reactions.

Contraindications and Precautions

Gastrointestinal ulcers: Contraindicated in patients with active gastrointestinal ulcers.

Renal impairment: Contraindicated in patients with severe renal impairment.

Liver disease: Contraindicated in patients with severe liver disease.

Pregnancy and lactation: Contraindicated during pregnancy and lactation.

Children under 12 years: Contraindicated due to lack of safety and efficacy data.

It's essential to consult with a healthcare professional before taking Sumo Tablets, especially if you have any underlying medical conditions or are taking other medications. If you experience any side effects, report them to your healthcare professional promptly.

Side Effects of Sumo Tablets with Prolonged Use

Prolonged use of Sumo Tablets can increase the risk of adverse effects, particularly gastrointestinal, renal, and hepatic complications. Here are some potential side effects associated with prolonged use:

Gastrointestinal Side Effects

Gastrointestinal ulcers: Increased risk of stomach and intestinal ulcers.

Gastrointestinal bleeding: Increased risk of bleeding in the stomach and intestines.

Gastrointestinal perforation: Rare but potentially life-threatening perforation of the stomach or intestines.

Diarrhea: Chronic diarrhea can lead to dehydration and electrolyte imbalances.

1. Abdominal pain: Persistent abdominal pain can be a sign of underlying gastrointestinal issues.

Renal Side Effects

Renal impairment: Prolonged use can lead to decreased kidney function.

Kidney damage: Long-term use can cause damage to kidney tissues.

Nephrotic syndrome: Rare but potentially life-threatening kidney condition.

Hepatic Side Effects

Elevated liver enzymes: Prolonged use can lead to increased levels of liver enzymes.

Liver damage: Long-term use can cause damage to liver tissues.

Hepatitis: Rare but potentially life-threatening liver inflammation.

Cardiovascular Side Effects

Increased blood pressure: Prolonged use can lead to increased blood pressure.

Cardiovascular events: Rare but potentially life-threatening events, such as heart attack, stroke, and cardiac arrhythmias.

Other Side Effects

Anemia: Prolonged use can lead to anemia due to gastrointestinal bleeding.

Osteoporosis: Long-term use can increase the risk of osteoporosis.

Immune system suppression: Prolonged use can weaken the immune system.

Monitoring and Precautions

To minimize the risk of side effects with prolonged use:

Regular monitoring: Regularly monitor liver and kidney function, blood pressure, and complete blood counts.

Dose adjustment: Adjust the dose as needed to minimize side effects.

Alternative therapies: Consider alternative therapies, such as topical NSAIDs or acetaminophen, for long-term pain management.

Also read Dolo- 650 tablet for pain relief

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Contraindications of Sumo Tablets

Sumo Tablets are contraindicated in the following conditions:

Absolute Contraindications

Hypersensitivity to Nimesulide or Paracetamol: Patients with a known hypersensitivity to Nimesulide or Paracetamol should not take Sumo Tablets.

Active Gastrointestinal Ulcers: Sumo Tablets are contraindicated in patients with active gastrointestinal ulcers, including stomach and duodenal ulcers.

Severe Renal Impairment: Patients with severe renal impairment (creatinine clearance < 30 mL/min) should not take Sumo Tablets.

Severe Hepatic Impairment: Patients with severe hepatic impairment (Child-Pugh Class C) should not take Sumo Tablets.

Pregnancy and Lactation: Sumo Tablets are contraindicated during pregnancy and lactation due to the potential risk of fetal harm and neonatal complications.

Relative Contraindications

Mild to Moderate Renal Impairment: Patients with mild to moderate renal impairment (creatinine clearance 30-60 mL/min) should use Sumo Tablets with caution and under close medical supervision.

Mild to Moderate Hepatic Impairment: Patients with mild to moderate hepatic impairment (Child-Pugh Class A or B) should use Sumo Tablets with caution and under close medical supervision.

Gastrointestinal Disorders: Patients with gastrointestinal disorders, such as Crohn's disease, ulcerative colitis, or gastrointestinal bleeding, should use Sumo Tablets with caution and under close medical supervision.

Cardiovascular Disease: Patients with cardiovascular disease, such as heart failure, coronary artery disease, or hypertension, should use Sumo Tablets with caution and under close medical supervision.

Elderly Patients: Elderly patients should use Sumo Tablets with caution and under close medical supervision due to the increased risk of adverse effects.

Use of Sumo Tablets in Pregnancy

Sumo Tablets are contraindicated during pregnancy due to the potential risk of fetal harm and neonatal complications. Here's a detailed overview:

Pregnancy Categories

Nimesulide: Pregnancy Category C (animal studies have shown adverse effects, but human studies are limited)

Paracetamol: Pregnancy Category B (animal studies have not shown adverse effects, but human studies are limited)

Risks Associated with Sumo Tablets in Pregnancy

Fetal harm: Nimesulide may cause fetal harm, particularly in the third trimester.

Premature closure of the ductus arteriosus: Nimesulide may cause premature closure of the ductus arteriosus, leading to fetal cardiac complications.

Neonatal complications: Paracetamol may cause neonatal complications, such as respiratory depression and hypoglycemia.

Safe Alternatives

Acetaminophen (Paracetamol) alone: Acetaminophen is generally considered safe during pregnancy, but it's essential to follow the recommended dosage and consult with a healthcare professional.

Ibuprofen: Ibuprofen is sometimes recommended during pregnancy, but only under close medical supervision.

Recommendations

Avoid Sumo Tablets during pregnancy: Due to the potential risks, it's recommended to avoid Sumo Tablets during pregnancy.

Consult a healthcare professional: If you're pregnant or planning to become pregnant, consult with a healthcare professional to discuss safe alternatives for pain management.

Pharmacokinetics of Nimesulide (Sumo Tablets)

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) that is widely used for its analgesic, antipyretic, and anti-inflammatory properties. Here's an overview of its pharmacokinetics:

Absorption

Nimesulide is rapidly absorbed after oral administration, with peak plasma concentrations reached within 2-3 hours.

The absolute bioavailability of nimesulide is approximately 80%.

Distribution

Nimesulide is highly bound to plasma proteins (>97%), mainly to albumin.

It has a relatively small volume of distribution (approximately 0.19 L/kg), indicating limited tissue distribution.

Metabolism

Nimesulide is extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C9 and CYP3A4.

The major metabolites are 4-hydroxynimesulide and 3-hydroxynimesulide.

Elimination

Nimesulide has a relatively short elimination half-life of approximately 2-5 hours.

The majority of the dose is excreted in the urine as metabolites, with a small amount excreted in the feces.

Pharmacokinetic Parameters

Peak plasma concentration (Cmax) :

2.5-5.5 μg/mL

Time to peak plasma concentration (Tmax):

2-3 hours

Elimination half-life (t1/2):

2-5 hours

Absolute bioavailability (F):

approximately 80%

Volume of distribution (Vd):

approximately 0.19 L/kg

USP of Sumo Tablets

The clinical USP (Unique Selling Proposition) of Sumo Tablets lies in their ability to provide effective pain relief and anti-inflammatory effects. Here are some key points that highlight the clinical USP of Sumo Tablets:

Pain Relief: Sumo Tablets are used to relieve pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis

Fever Reduction: They are also effective in reducing fever and relieving headaches, mild migraines, muscle pain, dental pain, and painful menstruation ².

Anti-Inflammatory Effects: The combination of Nimesulide and Paracetamol in Sumo Tablets works by blocking the production of chemical substances that cause pain and inflammation ².

Short-Term Pain Management: Sumo Tablets are recommended for short-term pain management, making them a useful option for patients who require quick relief from pain and inflammation ¹ ².

Overall, the clinical USP of Sumo Tablets lies in their ability to provide effective pain relief, reduce fever, and exert anti-inflammatory effects, making them a useful option for managing various painful conditions.

Frequently asked questions(FAQ) about Sumo Tablets:

What is Sumo Tablet used for?: Sumo Tablet is used to relieve pain, reduce inflammation, and lower fever.

What are the ingredients of Sumo Tablet?: Sumo Tablet contains Nimesulide (100mg) and Paracetamol (325mg).

How many Sumo Tablets can I take in a day?: The recommended dose is 1-2 tablets every 12 hours, not exceeding 3 tablets in 24 hours.

Can I take Sumo Tablet with other medications?: It's best to consult with your doctor before taking Sumo Tablet with other medications.

Is Sumo Tablet safe for pregnant women?: No, Sumo Tablet is contraindicated during pregnancy due to the potential risk of fetal harm.

Can I take Sumo Tablet for a long time?: No, Sumo Tablet is recommended for short-term use only. Long-term use can increase the risk of adverse effects.

What are the common side effects of Sumo Tablet?: Common side effects include nausea, vomiting, diarrhea, abdominal pain, and dizziness.

Can I take Sumo Tablet with food?: Yes, it's recommended to take Sumo Tablet with food to minimize stomach upset.

Is Sumo Tablet available over-the-counter?: Yes, Sumo Tablet is available over-the-counter, but it's always best to consult with your doctor before taking any medication.

Can I give Sumo Tablet to children?: No, Sumo Tablet is not recommended for children under 12 years old due to the lack of safety and efficacy data.

Here are some more frequently asked questions about Sumo Tablets:

How long does it take for Sumo Tablet to start working?: Sumo Tablet starts working within 30 minutes to 1 hour after taking the dose.

Can I take Sumo Tablet with other pain relievers?: No, it's not recommended to take Sumo Tablet with other pain relievers, such as ibuprofen or aspirin, without consulting your doctor.

Is Sumo Tablet safe for people with kidney problems?: No, Sumo Tablet is not recommended for people with severe kidney problems. Consult your doctor before taking Sumo Tablet if you have kidney problems.

Can I take Sumo Tablet with antacids?: Yes, you can take Sumo Tablet with antacids, but take them at least 2 hours apart.

Is Sumo Tablet safe for people with liver problems?: No, Sumo Tablet is not recommended for people with severe liver problems. Consult your doctor before taking Sumo Tablet if you have liver problems.

Can I take Sumo Tablet if I have a history of stomach ulcers?: No, Sumo Tablet is not recommended if you have a history of stomach ulcers. Consult your doctor before taking Sumo Tablet.

Is Sumo Tablet safe for people with high blood pressure?: Sumo Tablet can increase blood pressure. Consult your doctor before taking Sumo Tablet if you have high blood pressure.

Can I take Sumo Tablet with blood thinners?: No, Sumo Tablet can increase the risk of bleeding when taken with blood thinners. Consult your doctor before taking Sumo Tablet.

Is Sumo Tablet safe for people with asthma?: Sumo Tablet can trigger asthma attacks. Consult your doctor before taking Sumo Tablet if you have asthma.

Can I take Sumo Tablet if I have a history of allergic reactions?: No, Sumo Tablet is not recommended if you have a history of allergic reactions. Consult your doctor before taking Sumo Tablet.