Dolo 650 mg Tablet: Uses, Side Effects, Price, and Dosage

Are you experiencing mild to moderate pain due to headaches, toothaches, or muscle aches?

Look no further than Dolo 650 mg tab, a trusted and effective pain reliever. Containing 650mg of Paracetamol (Acetaminophen), Dolo 650 mg tab provides quick and sustained relief from pain and fever, helping you get back to your daily routine.

Key Benefits:

Relieves mild to moderate pain

Reduces fever

Fast-acting and long-lasting relief

Suitable for various types of pain, including headaches, toothaches, and muscle aches.

Composition of Dolo 650

Each Dolo 650 tablet contains:

Paracetamol (Acetaminophen) - 650mg

In India, Dolo 650 tablets are available in the following pack sizes:

10 tablets per strip (Alu-Alu blister pack)

15 tablets per strip (Alu-Alu blister pack)

20 tablets per strip (Alu-Alu blister pack)

The product is manufactured and marketed in India by Micro Labs Ltd.

Please note that the composition and packing information may be subject to change, and it's always best to check the packaging or consult with a healthcare professional for the most up-to-date information.

How Dolo 650 Works ?

What Happens When We Feel Pain?

When we get hurt or injured, our body sends signals to the brain, which interprets these signals as pain. These signals are like messages sent through a messenger.

How Does Dolo 650 Stop Pain?

Dolo 650 contains Paracetamol, which works by blocking the production of certain chemicals in the body called prostaglandins. These chemicals are like the messengers that carry pain signals to the brain.

When Paracetamol blocks prostaglandins, it essentially stops the pain messages from being sent to the brain. As a result, we don't feel the pain anymore.

How Does Dolo 650 Reduce Fever?

When we have a fever, our body temperature rises above normal. This is usually a response to an infection or illness.

Dolo 650 works by acting on the part of the brain that regulates body temperature, called the hypothalamus.

Paracetamol helps to reset the body's thermostat, bringing the temperature back down to normal.

Simple Analogy:

Think of pain and fever like a fire alarm. When the alarm goes off, it's like the pain or fever signal being sent to the brain.

Dolo 650 is like the fire alarm's off switch. It turns off the alarm, stopping the pain or fever signal from reaching the brain.

This helps us feel better and get back to our daily routine.

Dosage of Dolo 650

Dolo 650 is a brand of paracetamol (acetaminophen) used for pain relief and to reduce fever. The dosage depends on age, weight, and the condition being treated. Below are general guidelines:

For Adults:

Recommended Dose: 1 tablet (650 mg) every 4–6 hours as needed.

Maximum Dose: Do not exceed 4,000 mg (6 tablets) in 24 hours.

Usage: Take with water after meals to reduce stomach upset.

For Children (12–18 years):

Recommended Dose: 1 tablet (650 mg) every 4–6 hours as needed.

Maximum Dose: Do not exceed 4,000 mg (6 tablets) in 24 hours.

For Children (below 12 years):

The dosage is usually calculated based on weight: 10–15 mg/kg body weight every 4–6 hours as needed.

Dolo 650 is generally not recommended for children below 12 years. Instead, pediatric formulations of paracetamol should be used. Consult a doctor for precise dosing.

Precautions:

1. Do not exceed the recommended dose as it may cause liver damage.

2. Avoid using Dolo 650 if you have liver or kidney disease, or if advised by your doctor.

3. Do not take with alcohol as it increases the risk of liver damage.

4. If symptoms persist for more than 3 days (fever) or 5 days (pain), consult a doctor

For personalized dosing, always consult a healthcare professional

Side effects of Dolo 650

Dolo 650 (paracetamol/acetaminophen) is generally safe when taken at recommended doses, but it can cause side effects in some cases. These side effects can range from mild to severe and are often dose-dependent. Below is a detailed breakdown:

Common Side Effects (Usually Mild):

Nausea

Vomiting

Stomach pain or discomfort

Loss of appetite

Less Common Side Effects:

Skin rash

Itching or redness

Dizziness

Fatigue

Rare but Serious Side Effects:

These usually occur with an overdose, long-term use, or in individuals with pre-existing conditions.

Liver damage: Symptoms include jaundice (yellowing of the skin/eyes), dark urine, or pale stools.

Kidney damage: Decreased urine output or swelling in the legs/ankles.

Severe allergic reactions (rare):

Symptoms: Difficulty breathing, swelling of the face, throat, or tongue (angioedema), and hives.

Blood disorders: Reduced blood cell counts, leading to symptoms like fatigue, easy bruising, or frequent infections.

Skin reactions: Rare but severe skin conditions like Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Overdose Symptoms:

An overdose of Dolo 650 can cause serious complications, particularly liver failure. Symptoms of overdose include:

Extreme nausea and vomiting

Loss of appetite

Confusion or drowsiness

Severe abdominal pain

Sweating or clamminess

Yellowing of the skin/eyes (jaundice)

Dark urine

Important: If an overdose is suspected, seek medical help immediately. Activated charcoal or acetylcysteine may be used as an antidote in a hospital setting.

Precautions to Minimize Side Effects:

1. Avoid Alcohol: Combining alcohol with paracetamol increases the risk of liver damage.

2. Follow Dosage Guidelines: Do not exceed the recommended dose (max 4,000 mg/day for adults).

3. Pre-existing Conditions: Consult a doctor if you have liver or kidney disease before taking Dolo 650.

4. Medication Interactions: Avoid combining Dolo 650 with other medications containing paracetamol to prevent overdose.

If you experience any severe or unusual side effects, stop the medication and consult a healthcare provider immediately

Pharmacokinetics of Dolo 650

Dolo 650, containing Paracetamol (Acetaminophen) 650mg, exhibits the following pharmacokinetic properties:

Absorption:

Route of Administration: Oral

Absorption Rate: Rapid

Peak Plasma Concentration (Tmax): 30 minutes to 1 hour

Bioavailability: Approximately 80-100%

Distribution:

Volume of Distribution (Vd): 0.9-1.3 L/kg

Protein Binding: Less than 10% bound to plasma proteins

Metabolism:

Metabolic Pathway: Hepatic, primarily via glucuronidation and sulfation

Major Metabolites: Paracetamol glucuronide, paracetamol sulfate, and N-acetyl-p-benzoquinone imine (NAPQI)

Excretion:

Renal Excretion: Primarily through kidneys

Elimination Half-Life (t1/2): 2-3 hours

Total Clearance: 5-7 mL/min/kg

Special Populations:

Pediatric Patients: Pharmacokinetics similar to adults

Geriatric Patients: May have reduced clearance and increased t1/2

Hepatic Impairment: May have reduced clearance and increased t1/2

Renal Impairment: May have reduced clearance and increased t1/2

Please note that these pharmacokinetic parameters are approximate and may vary depending on individual factors, such as age, weight, and liver or kidney function.

Contraindications of Dolo 650

Dolo 650 is contraindicated in the following conditions:

Absolute Contraindications:

Known hypersensitivity to Paracetamol (Acetaminophen): Patients who have previously experienced an allergic reaction to Paracetamol should not take Dolo 650.

Severe liver impairment: Patients with severe liver disease or liver failure should not take Dolo 650.

Severe kidney impairment: Patients with severe kidney disease or kidney failure should not take Dolo 650.

Relative Contraindications:

Mild to moderate liver impairment: Patients with mild to moderate liver disease should use Dolo 650 with caution and under medical supervision.

Mild to moderate kidney impairment: Patients with mild to moderate kidney disease should use Dolo 650 with caution and under medical supervision.

Chronic alcoholism: Patients who consume excessive alcohol should use Dolo 650 with caution, as it may increase the risk of liver damage.

Malnutrition: Patients who are malnourished or have a low body mass index (BMI) should use Dolo 650 with caution.

Pregnancy and lactation: Dolo 650 should be used with caution during pregnancy and lactation, and only under medical supervision.

Other Contraindications:

Concomitant use with other Paracetamol-containing products: Patients should not take Dolo 650 with other products that contain Paracetamol, as it may increase the risk of overdose.

Concomitant use with warfarin: Patients taking warfarin should use Dolo 650 with caution, as it may increase the risk of bleeding.

Drug Interactions of Dolo 650

Dolo 650, containing Paracetamol (Acetaminophen) 650mg, may interact with the following medications:

Major Interactions:

Warfarin: Concomitant use of Dolo 650 and warfarin may increase the risk of bleeding.

Anticonvulsants (e.g., phenytoin, carbamazepine): Long-term use of Dolo 650 with anticonvulsants may increase the risk of liver damage.

Rifampicin: Concomitant use of Dolo 650 and rifampicin may decrease the effectiveness of Dolo 650.

Cholestyramine: Concomitant use of Dolo 650 and cholestyramine may decrease the absorption of Dolo 650.

Moderate Interactions:

Anticoagulants (e.g., aspirin, heparin): Concomitant use of Dolo 650 and anticoagulants may increase the risk of bleeding.

Oral hypoglycemic agents (e.g., metformin): Concomitant use of Dolo 650 and oral hypoglycemic agents may increase the risk of hypoglycemia.

Blood thinners (e.g., clopidogrel): Concomitant use of Dolo 650 and blood thinners may increase the risk of bleeding.

Minor Interactions:

Antacids (e.g., aluminum hydroxide): Concomitant use of Dolo 650 and antacids may decrease the absorption of Dolo 650.

Histamine H2-receptor antagonists (e.g., ranitidine): Concomitant use of Dolo 650 and histamine H2-receptor antagonists may decrease the absorption of Dolo 650.

Food Interactions:

Caffeine: Excessive caffeine consumption may increase the risk of liver damage when taken with Dolo 650.

Alcohol: Excessive alcohol consumption may increase the risk of liver damage when taken with Dolo 650.

Frequently asked questions about Dolo 650 (FAQ)

1. What is Dolo 650 used for?

Dolo 650 is used for relieving mild to moderate pain and reducing fever. It is commonly used to treat headaches, toothaches, muscle aches, backaches, and menstrual cramps.

2. Is Dolo a strong painkiller?

Dolo 650 contains Paracetamol (Acetaminophen) 650mg, which is a mild to moderate pain reliever. It is not considered a strong painkiller, but it is effective for relieving everyday aches and pains.

3. Can Dolo be taken on an empty stomach?

It is recommended to take Dolo 650 with food or milk to avoid stomach upset. Taking it on an empty stomach may increase the risk of stomach irritation and other gastrointestinal side effects.

4. Can I take 2 Dolo 650 in a day?

The recommended dosage of Dolo 650 is 1 tablet every 4-6 hours as needed, not to exceed 4 tablets in 24 hours. Taking more than the recommended dose can increase the risk of liver damage and other side effects.

5. Does Dolo make you sleepy?

Dolo 650 is not typically known to cause drowsiness or sleepiness. However, some people may experience dizziness or drowsiness after taking Dolo 650, especially if they are sensitive to the medication or take it with other sedating medications.

6. Does Dolo 650 affect the kidneys?

Dolo 650 is primarily metabolized by the liver and excreted by the kidneys. While it is generally safe for people with normal kidney function, it may not be suitable for people with severe kidney impairment or kidney failure.

7. Which is better, Dolo or Crocin?

Both Dolo 650 and Crocin are popular pain relievers containing Paracetamol (Acetaminophen). The choice between the two depends on individual preferences and needs. Some people may prefer Dolo 650 for its faster onset of action, while others may prefer Crocin for its longer duration of action.

8. Is Dolo an antibiotic?

No, Dolo 650 is not an antibiotic. It is a pain reliever and antipyretic (fever reducer) that contains Paracetamol (Acetaminophen).

9. Is Dolo 650 banned in India in 2018?

No, Dolo 650 was not banned in India in 2018. In fact, it remains one of the most widely used and prescribed pain relievers in India.

10. What is the difference between paracetamol and Dolo 650?

Paracetamol and Dolo 650 are essentially the same thing. Paracetamol is the active ingredient in Dolo 650, which is a brand name for the medication. Dolo 650 contains 650mg of Paracetamol per tablet.

11. Which is better Combiflam or Dolo 650?

Combiflam and Dolo 650 are both pain relievers, but they contain different active ingredients. Combiflam contains a combination of ibuprofen and paracetamol, while Dolo 650 contains only paracetamol. The choice between the two depends on individual needs and preferences.

12. Does Dolo have aspirin?

No, Dolo 650 does not contain aspirin. It contains only paracetamol (acetaminophen) 650mg.

13. What is the age limit for paracetamol 650?

Paracetamol 650mg is generally recommended for adults and children above 12 years of age. However, the dosage and age limit may vary depending on individual needs and medical conditions.

14. Can a sugar patient take Dolo?

Yes, sugar patients (diabetics) can take Dolo 650, but they should consult their doctor before taking it. Dolo 650 does not contain sugar, but it may affect blood sugar levels.

15. Can I take Dolo 650 for cold and cough?

Dolo 650 can help relieve headaches, fever, and body aches associated with cold and cough. However, it does not treat the underlying cause of the cold and cough.

16. What happens if we use Dolo 650 without fever?

Taking Dolo 650 without fever will not cause harm, but it may not provide any benefits either. Dolo 650 is primarily used to reduce fever and relieve pain.

17. Can I take cetirizine and Dolo 650 together?

Yes, you can take cetirizine (an antihistamine) and Dolo 650 together, but you should consult your doctor before taking them. There are no known interactions between cetirizine and paracetamol.

18. Is Dolo 650 safe?

Dolo 650 is generally considered safe when taken as directed. However, it may cause side effects such as nausea, vomiting, and stomach upset in some individuals.

19. What happens if we take Dolo 650 without food?

Taking Dolo 650 without food may increase the risk of stomach upset, nausea, and vomiting.

20. Does Dolo 650 affect the kidneys?

Dolo 650 is primarily metabolized by the liver and excreted by the kidneys. While it is generally safe for people with normal kidney function, it may not be suitable for people with severe kidney impairment or kidney failure.

21. Can we take azithromycin with Dolo?

Yes, you can take azithromycin (an antibiotic) with Dolo 650, but you should consult your doctor before taking them. There are no known interactions between azithromycin and paracetamol.

22. Is Dolo 650 an antibiotic?

No, Dolo 650 is not an antibiotic. It is a pain reliever and antipyretic (fever reducer) that contains paracetamol (acetaminophen).

23. Can I take Dolo 650 after eating chicken?

Yes, you can take Dolo 650 after eating chicken or any other food. However, it is recommended to take Dolo 650 with food to avoid stomach upset.

24. How much time does Dolo 650 take to reduce fever?

Dolo 650 typically starts to reduce fever within 30 minutes to 1 hour after ingestion. The maximum effect is usually seen within 2-3 hours.

25. Can I take Dolo 650 during pregnancy?

It is recommended to consult a doctor before taking Dolo 650 during pregnancy. While paracetamol is generally considered safe during pregnancy, high doses or prolonged use may increase the risk of liver damage.

26. Can I take Dolo 650 while breastfeeding?

It is recommended to consult a doctor before taking Dolo 650 while breastfeeding. Paracetamol is excreted in breast milk, but the amount is generally considered safe for infants.

27. Can I give Dolo 650 to my child?

Dolo 650 is not recommended for children below 12 years of age. For children above 12 years of age, the recommended dose is 1 tablet every 4-6 hours as needed, not to exceed 4 tablets in 24 hours.

28. Can I take Dolo 650 with other pain relievers?

It is not recommended to take Dolo 650 with other pain relievers, such as ibuprofen or aspirin, without consulting a doctor. Combining pain relievers may increase the risk of side effects.

29. Can I take Dolo 650 for menstrual cramps?

Yes, Dolo 650 can be taken to relieve menstrual cramps. However, it is recommended to consult a doctor if the cramps are severe or persistent.

30. Can I take Dolo 650 for headaches?

Yes, Dolo 650 can be taken to relieve headaches. However, it is recommended to consult a doctor if the headaches are frequent, severe, or persistent.

31. Can I take Dolo 650 with antacids?

Yes, Dolo 650 can be taken with antacids. However, it is recommended to take the antacid at least 2 hours after taking Dolo 650.

32. Can I crush or chew Dolo 650 tablets?

No, it is not recommended to crush or chew Dolo 650 tablets. This may affect the release of the active ingredient and increase the risk of side effects.

33. Can I take Dolo 650 with herbal supplements?

It is recommended to consult a doctor before taking Dolo 650 with herbal supplements. Some herbal supplements may interact with paracetamol and increase the risk of side effects.

34. What should I do if I miss a dose of Dolo 650?

If you miss a dose of Dolo 650, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

35.List some substitutes of Dolo 650 with company name.

Here are some substitutes for Dolo 650:

Crocin 650 MG Tablet: Glaxosmithkline Pharmaceuticals Ltd, ₹29.90 for a strip of 15 tablets

Calpol 650 MG Tablet: Glaxosmithkline Pharmaceuticals Ltd, ₹29.90 for a strip of 15 tablets

Doliprane 650 MG Tablet: Abbott Healthcare Pvt. Ltd

Paracip 650 MG Tablet: Cipla Ltd

Lanol ER 650mg Tablet: Hetero Healthcare Ltd,